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The Role of Orexin in the Arousal System: Implications for Sleep-Wake Medicine  

11-29-2012

Orexins, also called hypocretins, are novel peptides that act as neurotransmitters to modulate several body systems and processes, including the arousal system and wakefulness. First discovered in the late 1990s and initially investigated in narcolepsy, these peptides are now at the center of growing excitement and scientific and clinical discussions related to their implications for therapies in sleep-wake medicine. In particular, the orexin system is serving as a therapeutic target to develop agents for insomnia and narcolepsy.

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Filetype: MP4 - Size: 124.46MB - Duration: 21:08 m